DNA Structure and Replication problems
- 1. What is the only common methylation in the DNA of eukaryotes?
Options- A. Adenosine in GpA dinucleotides
- B. Guanosine in ApGpA trinucleotides
- C. Cytosine in CpG dinucleotides
- D. None of the above Discuss
Correct Answer: Cytosine in CpG dinucleotides
- 2. Which histone(s) are associated with the linker DNA of a nucleosome?
Options- A. Histone H1
- B. Histones H2A and H2B
- C. Histone H3
- D. Histone H4 Discuss
Correct Answer: Histone H1
- 3. Okazaki fragments occur during
Options- A. transformation
- B. replication
- C. polymerase reaction
- D. synthesis Discuss
Correct Answer: replication
- 4. DNA can be sequenced by the
Options- A. chemical method
- B. chain termination procedure
- C. both (a) and (b)
- D. physical method Discuss
Correct Answer: both (a) and (b)
- 5. DNA replication takes place in which direction?
Options- A. 3' to 5'
- B. 5 'to 3'
- C. Randomly
- D. Vary from organism to organism Discuss
Correct Answer: 5 'to 3'
- 6. E.coli DNA polymerases II and III lack
Options- A. 5' ? 3' exonuclease activity
- B. 5' ? 3' endonuclease activity
- C. partially 5' ? 3' exonuclease activity
- D. partially 5' ? 3' endonuclease activity Discuss
Correct Answer: 5' ? 3' exonuclease activity
- 7. The nucleosome consists of histone
Options- A. octamer and 146 bp of DNA
- B. tetramer and 146 bp of DNA
- C. hexamer and 146 bp of DNA
- D. none of the above Discuss
Correct Answer: octamer and 146 bp of DNA
- 8. What is the range of melting point temperatures (Tm) for most DNA molecules?
Options- A. 50 to 60°C
- B. 60 to 80°C
- C. 70 to 90°C
- D. 80 to l00°C Discuss
Correct Answer: 80 to l00°C
- 9. Taylor, Woods and Hughes labeled Vicia DNA by allowing new DNA synthesis in the presence of radioactive thymine. After DNA replication (S phase of the cell cycle), it was observed that
Options- A. only one chromatid of a chromosome was labeled
- B. both chromatids of a chromosome were labeled
- C. both (a) and (b)
- D. neither chromatid was labeled Discuss
Correct Answer: both chromatids of a chromosome were labeled
- 10. What bands will be observed in a cesium chloride gradient after two rounds of replication?
Options- A. One light, one medium and one heavy band
- B. One light and one medium band
- C. One medium band
- D. One medium and one heavy band Discuss
Correct Answer: One light and one medium band
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