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DNA Structure and Replication problems


  • 1. The rapid appearance of HIV-1 strains that are resistant to AIDS drugs is due in part to which of the following property of its reverse transcriptase?

  • Options
  • A. AZT (zidovudine) is too expensive to be taken in effective doses
  • B. The RNase H domain of p66 causes error prone synthesis
  • C. It lacks a proofreading exonuclease
  • D. It has low affinity for the correct dNTP's
  • Discuss
  • 2. 30 nm wide helix with five or six nucleosomes per helix is known as

  • Options
  • A. solenoid
  • B. halonoid
  • C. kinoplast
  • D. none of these
  • Discuss
  • 3. What is the approximate percentage of repetitive DNA sequences in human DNA?

  • Options
  • A. 10 to 20%
  • B. 20 to 30%
  • C. 30 to 40%
  • D. 40 to 50%
  • Discuss
  • 4. Okazaki fragments occur on the __________ and are bonded together by __________

  • Options
  • A. Leading strand, polymerase
  • B. mRNA, anticodons
  • C. Lagging strand, ligase
  • D. tRNA, polymerase
  • Discuss
  • 5. Overwinding or overtightening of DNA during replication is caused and removed by

  • Options
  • A. DNAb, DNA polymerase
  • B. DNAa, gyrase
  • C. DNAb, gyrase
  • D. Single stranded protein, DNAa
  • Discuss
  • 6. In a cesium chloride gradient, DNA labeled with 15N and centrifuged will form a band

  • Options
  • A. above DNA containing 14N
  • B. below DNA containing 14N
  • C. with 14N-containing DNA
  • D. all of these
  • Discuss
  • 7. Which enzyme catalyzes the elongation of DNA molecules?

  • Options
  • A. DNA polymerase
  • B. Helicase
  • C. DNA ligase
  • D. Primase
  • Discuss
  • 8. Deoxyribonucleoside triphosphates, being need in the chain termination methods are

  • Options
  • A. dATP
  • B. dGTP and dCTP
  • C. dTTP
  • D. all of these
  • Discuss
  • 9. Reverse transcriptase produces

  • Options
  • A. DNA from peptides
  • B. RNA from DNA
  • C. RNA from RNA
  • D. DNA from RNA
  • Discuss
  • 10. Without telomerase, what would happen to the ends of chromosomes after each round of replication?

  • Options
  • A. Chromosomes would become progressively shorter
  • B. Nothing would happen
  • C. Chromosomes would get longer
  • D. none of the above
  • Discuss

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