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Home Biochemistry Cell Signalling and Transduction Comments

  • Question
  • The enzyme that catalyzes the splitting of PIP2 into two molecules of inositol triphosphate (IP3) and diacylglycerol in cell signaling, is


  • Options
  • A. phosphokinase C
  • B. phospholipase C
  • C. phosphodiesterase C
  • D. lipokinase

  • Correct Answer
  • phospholipase C 


  • Cell Signalling and Transduction problems


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    • 1. The binding of ligands to many G-proteins linked receptors leads to shortlived

    • Options
    • A. increase in the concentration of certain intracellular signaling molecules called second messenger
    • B. decrease in the concentration of certain intracellular signaling molecules called second messenger
    • C. increase in the concentration of certain extracellular signaling molecules called first messenger
    • D. decrease in the concentration of certain extracellular signaling molecules called first messenger
    • Discuss
    • 2. Simple nerve reflexes use signaling molecules called

    • Options
    • A. neurotransmitters
    • B. nitric oxides
    • C. G proteins
    • D. proteases
    • Discuss
    • 3. The major second messengers are

    • Options
    • A. cAMP
    • B. cGMP
    • C. DAG
    • D. All of these
    • Discuss
    • 4. Cell signaling can be classified into

    • Options
    • A. three distinct types based on the distance over which the signaling molecules act
    • B. two distinct types based on the distance over which the signaling molecules act
    • C. three distinct types based on the signaling molecules
    • D. none of the above
    • Discuss
    • 5. The hormone or ligand can be considered as

    • Options
    • A. first messenger
    • B. second messenger
    • C. both (a) and (b)
    • D. none of these
    • Discuss
    • 6. Which of the following statement is incorrect?

    • Options
    • A. The principal lipophilic hormones that binds to receptors located in the plasma membranes are prostaglandins
    • B. Prostaglandins are synthesized from arachidonic acid
    • C. Prostaglandins act as paracrine signaling molecules
    • D. None of the above
    • Discuss
    • 7. In paracrine signaling, the signaling molecules affects only

    • Options
    • A. target cells close to the cell from which it was secreted
    • B. target cells distant from its site of synthesis in cells of an endocrine organ
    • C. both (a) and (b)
    • D. none of the above
    • Discuss
    • 8. A signal cascade induced by adrenaline or thyroxine

    • Options
    • A. must begin with receipt of the signal molecule by a surface receptor
    • B. involves the activation of a G protein
    • C. results in the activation of a sequence of enzymes needed for the cell effect
    • D. all of the above
    • Discuss
    • 9. Self-phosphorylation is an excellent mechanism for triggering specific catalytic function of the proteins involved in signal cascades because it

    • Options
    • A. changes the shape and thus the enzymatic activity of the proteins involved
    • B. makes the receptor more likely to capture the signaling, molecule
    • C. allows hydrophilic signaling molecules to cross the plasma membrane
    • D. None of the above
    • Discuss
    • 10. Which of the following is not a type of signaling molecule?

    • Options
    • A. Testosterone
    • B. Insulin
    • C. Thyroxin
    • D. Adenylate cyclase
    • Discuss


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