enzymes biochemistry question and answers -Page 2

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Enzymes problems

1. How is the enzyme COX-1 important in human health?
Options
A. It helps to transport carbon dioxide in the blood
B. It is critical for the biosynthesis of DNA
C. It is a chemical derivative of aspirin
D. It catalyzes the production of hormones that maintain the stomach lining

2. Which of the common features are shared between serine and aspartate proteases?
Options
A. Both require water to complete the catalytic cycle
B. Both use a base to activate the nucleophile
C. Both show specificity for certain amino acid sequences
D. All of the above

3. The role of Asp 102 and His 57 during trypsin catalysis is to
Options
A. neutralize the charge on the other's side chain
B. keep the specificity pocket open
C. function as a proton shuttle
D. clamp the substrate into the active site

4. The E.coli pyruvic acid dehydrogenase complex is reported to
Options
A. decatalyze the oxidation of pyruvic acid to acetyl Co A and CO₂
B. Catalyze the oxidation of pyruvic acid to acetyl Co A and CO₂
C. retard the reduction of pyruvic acid to acetyl Co A and CO₂
D. Catalyze the reduction of pyruvic acid to acetyl Co A and CO₂

5. The cleavage specificity of trypsin and chymotrypsin depend in part on the
Options
A. proximity of Ser 195 to the active site or specificity pocket
B. size, shape, and charge of the active site or specificity pocket
C. presence of a low-barrier hydrogen bond in the active site or specificity pocket
D. absence of water in the active site

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