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- Question
Difficulties with somatic gene therapy arise from all of the following except
Options- A. GVHD caused by mature T cells in the transplanted cells
- B. inserting a gene so that it will function properly
- C. limited life span of more mature hematopoietic cells
- D. transducing genetic material into stem cells
- Correct Answer
- GVHD caused by mature T cells in the transplanted cells
- 1. Which of the Rous sarcoma virus has a homologous cellular protein?
Options- A. c-src
- B. v-src
- C. v-ha-src
- D. v-ha-ras Discuss
- 2. Combined cellular and humoral immune deficiencies result from lack of all of the following except
Options- A. a thymus
- B. class II MHC
- C. HIV infection of CD4+ T cells
- D. transporter of antigen peptides (TAP) Discuss
- 3. Bone marrow given to an infant with SCID must
Options- A. be irradiated to eliminate GVHD
- B. contain mature T cells that can begin making immune responses immediately
- C. come from a donor that shares some MHC alleles with the recipient
- D. come from one of the child's parents Discuss
- 4. A selective IgA deficiency would be expected to result in problems with
Options- A. bacterial infections
- B. infections following dental work due to bacteria entering the bloodstream
- C. mucosal pathogens
- D. pathogens which can survive inside macrophages Discuss
- 5. To treat HIV infections using drugs, the major problem is that
Options- A. the drugs that are good inhibitors cannot by synthesized
- B. the drugs interfere with normal digestion
- C. the virus particles with altered (mutant) proteases arise
- D. the drugs are rapidly degraded Discuss
- 6. X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be
Options- A. activation of B cells by T-independent antigens
- B. failure of B cells to provide co-stimulation for Th2 activation
- C. failure of Th2 cells to provide co-stimulation for B cell isotype switching
- D. failure of Th2 cells to provide co-stimulation for B cell proliferation Discuss
- 7. An autoimmune disease is
Options- A. AIDS
- B. Measles
- C. Lupus
- D. Mumps Discuss
- 8. Specific translocations are associated with
Options- A. colon cancer
- B. breast cancer
- C. pancreatic cancer
- D. some leukemias Discuss
- 9. Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with
Options- A. CTL killing of viruses
- B. dendritic cell activation to become a mature APC
- C. infected cell processing of virus peptides
- D. macrophage intracellular killing of bacteria Discuss
- 10. Infants are most susceptible to bacterial infection due to low circulating levels of IgG
Options- A. in utero (before birth)
- B. at 0-3 months of age
- C. at 3-12 months of age
- D. at 12-24 months of age Discuss
Disease Associated with Immune System problems
Search Results
Correct Answer: c-src
Correct Answer: transporter of antigen peptides (TAP)
Correct Answer: come from a donor that shares some MHC alleles with the recipient
Correct Answer: mucosal pathogens
Correct Answer: the virus particles with altered (mutant) proteases arise
Correct Answer: failure of Th2 cells to provide co-stimulation for B cell isotype switching
Correct Answer: Lupus
Correct Answer: some leukemias
Correct Answer: macrophage intracellular killing of bacteria
Correct Answer: at 3-12 months of age
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