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Home Biochemistry Transcription and Regulation Comments

  • Question
  • The major function of RNA polymerase's sigma factor is


  • Options
  • A. recognition of the translational stop sequence
  • B. recognition of the transcriptional start sequence
  • C. recognition of the transcriptional stop sequence
  • D. recognition of the translational start sequence

  • Correct Answer
  • recognition of the transcriptional start sequence 


  • Transcription and Regulation problems


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    • 1. Transcription begins

    • Options
    • A. at the start codon
    • B. upstream from the start codon
    • C. downstream from the start codon
    • D. none of these
    • Discuss
    • 2. RNA is synthesized on a DNA template in a process called __________ , which utilizes the enzyme __________

    • Options
    • A. translation, RNA polymerase
    • B. transcription, DNA polymerase
    • C. transcription, RNA polymerase
    • D. replication, DNA polymerase
    • Discuss
    • 3. Transcription of each set of rRNA genes by RNA polymerasel produces

    • Options
    • A. a single 45S rRNA precursor molecule
    • B. a single 5S rRNA precursor molecule
    • C. a single 18S rRNA precursor molecule
    • D. a single 28S rRNA precursor molecule
    • Discuss
    • 4. Multiple copies of 5S genes, located at a chromosomal site distinct from the other rRNA genes

    • Options
    • A. are transcribed by rRNA polymerase III and the 5S rRNA
    • B. are transcribed by rRNA polymerase II
    • C. are transcribed by rRNA polymerase I and the 5S rRNA
    • D. are transcribed by DNA polymerase I
    • Discuss
    • 5. Transcription by E. coli polymerase occurs in

    • Options
    • A. four phases known as initiation, propagation, elongation and termination
    • B. three phases known as initiation, elongation and termination
    • C. two phases known as initiation and termination
    • D. none of the above
    • Discuss
    • 6. Marfan's syndrome is thought to be a mutation affecting

    • Options
    • A. hemoglobin synthesis
    • B. collagen synthesis
    • C. metabolism of homogentisic acid
    • D. insufficient thyroid production
    • Discuss
    • 7. BRACl, an inherited form of breast cancer, regulates cell division by

    • Options
    • A. binding to a DNA sequence
    • B. complexing with cyclins
    • C. binding to the cell outer membrane
    • D. binding to the protein RAD 51 which repairs DNA damage
    • Discuss
    • 8. Individuals with PKU disease are mentally retarded unless

    • Options
    • A. phenylalanine in the diet is restricted
    • B. tyrosine in the diet is restricted
    • C. homogentisic acid in the diet is restricted
    • D. none of the above
    • Discuss
    • 9. Cyclins are proteins that

    • Options
    • A. regulate ability of cells to invade tissue
    • B. regulate passage from one stage of cell division to another
    • C. regulate apoptosis of damaged cells
    • D. none of the above
    • Discuss
    • 10. Over 50% of common cancers are associated with damage to a protein, p53. This protein

    • Options
    • A. is a cyclin
    • B. is a tumor supressor
    • C. is an oncogene
    • D. regulates apoptosis
    • Discuss


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