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- Question
O2 binding to hemoglobin results in
Options- A. 100-fold higher affinity for the last O2 bound than for the first
- B. extensive protein conformational change
- C. both (a) and (b)
- D. 100-fold lower affinity for the last O2 bound than for the first
- Correct Answer
- both (a) and (b)
- 1. A protein that binds two ligands in a non-cooperative manner will show
Options- A. a sigmodial binding curve
- B. a hyperbolic binding curve
- C. a linear Scatchard Plot
- D. both (b) and (c) Discuss
- 2. The specificity of a ligand binding site on a protein is based on
Options- A. the absence of competing ligands
- B. the amino acid residues lining the binding site
- C. the presence of hydrating water molecules
- D. the opposite chirality of the binding ligand Discuss
- 3. When protein binds two ligands in a non-cooperative manner, then the x-intercept of the Scatchard Plot is
Options- A. 1
- B. 2
- C. not defined
- D. none of the above Discuss
- 4. The conformational changes from the T to the R state is initiated by
Options- A. binding of oxygen to the heme
- B. movement of the proximal histidine towards the heme
- C. movement of the F-helix, which contains the proximal His
- D. reorganization of protein-protein contacts between the individual subunits Discuss
- 5. An allosteric activator
Options- A. increases the binding affinity
- B. decreases the binding affinity
- C. stabilizes the R state of the protein
- D. both (a) and (c) Discuss
- 6. In hemoglobin, allosteric effects occur
Options- A. only in humans
- B. for maintaining Fe in the Fe2+ state
- C. to minimize oxygen delivery to the tissues
- D. to maximize oxygen delivery to the tissues Discuss
- 7. Bisphosphoglycerate (BPG) cannot bind to the oxygenated R state of hemoglobin because
Options- A. it is displaced from the heme by oxygen
- B. it is displaced from the heme by movement of the proximal histidine
- C. its binding pocket becomes too small to accommodate BPG
- D. BPG binds to the R state with the same affinity as the T state Discuss
- 8. Small molecules affect hemoglobin (Hb) by
Options- A. decreasing Hb affinity for O2
- B. increasing [H+]
- C. increasing Hb affinity for O2
- D. increasing [H+] and decreasing Hb affinity for O2 Discuss
- 9. A protein that shows infinite cooperative for binding of n ligands will
Options- A. show a Hill coefficient (nH) of 0.0
- B. only be found in either the unliganded form or the fully liganded form
- C. show a Hill coefficient (nH) of n
- D. both (b) and (c) Discuss
- 10. Which of the following is most likely to produce anaphylaxis in a susceptible individual?
Options- A. Pollen
- B. Mold
- C. Dust
- D. Bee sting Discuss
Allosteric Effects problems
Search Results
Correct Answer: both (b) and (c)
Correct Answer: the amino acid residues lining the binding site
Correct Answer: 2
Correct Answer: binding of oxygen to the heme
Correct Answer: both (a) and (c)
Correct Answer: to maximize oxygen delivery to the tissues
Correct Answer: its binding pocket becomes too small to accommodate BPG
Correct Answer: increasing [H+] and decreasing Hb affinity for O2
Correct Answer: both (b) and (c)
Correct Answer: Bee sting
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