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Home Biochemistry DNA Structure and Replication Comments

  • Question
  • The rapid appearance of HIV-1 strains that are resistant to AIDS drugs is due in part to which of the following property of its reverse transcriptase?


  • Options
  • A. AZT (zidovudine) is too expensive to be taken in effective doses
  • B. The RNase H domain of p66 causes error prone synthesis
  • C. It lacks a proofreading exonuclease
  • D. It has low affinity for the correct dNTP's

  • Correct Answer
  • It lacks a proofreading exonuclease 


  • DNA Structure and Replication problems


    Search Results


    • 1. The nicks or gaps between Okazaki fragments are eventually sealed by

    • Options
    • A. gyrase
    • B. DNA ligase
    • C. RNA ligase
    • D. polymerase
    • Discuss
    • 2. Each replication bubbles consists of

    • Options
    • A. 3 replication forks
    • B. 2 replication forks
    • C. 4 replication forks
    • D. 1 replication forks
    • Discuss
    • 3. The packing ratio of nucleosomes is about

    • Options
    • A. 6
    • B. 8
    • C. 7
    • D. 9
    • Discuss
    • 4. The enzyme responsible for breaking the hydrogen bonds, and thus separating the DNA strands during DNA synthesis is

    • Options
    • A. DNA polymerase
    • B. strandase
    • C. helicase
    • D. none of these
    • Discuss
    • 5. Which of the following species lack a 'classical' histone H1?

    • Options
    • A. Saccharomyces cerevisiae
    • B. Strongylocentrotus purpuratus
    • C. Xenopus laevis
    • D. Arabidopsis thaliana
    • Discuss
    • 6. 30 nm wide helix with five or six nucleosomes per helix is known as

    • Options
    • A. solenoid
    • B. halonoid
    • C. kinoplast
    • D. none of these
    • Discuss
    • 7. What is the approximate percentage of repetitive DNA sequences in human DNA?

    • Options
    • A. 10 to 20%
    • B. 20 to 30%
    • C. 30 to 40%
    • D. 40 to 50%
    • Discuss
    • 8. Okazaki fragments occur on the __________ and are bonded together by __________

    • Options
    • A. Leading strand, polymerase
    • B. mRNA, anticodons
    • C. Lagging strand, ligase
    • D. tRNA, polymerase
    • Discuss
    • 9. Overwinding or overtightening of DNA during replication is caused and removed by

    • Options
    • A. DNAb, DNA polymerase
    • B. DNAa, gyrase
    • C. DNAb, gyrase
    • D. Single stranded protein, DNAa
    • Discuss
    • 10. In a cesium chloride gradient, DNA labeled with 15N and centrifuged will form a band

    • Options
    • A. above DNA containing 14N
    • B. below DNA containing 14N
    • C. with 14N-containing DNA
    • D. all of these
    • Discuss


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