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Home Biochemistry Structure and Properties of Peptides Comments

  • Question
  • In deoxy hemoglobin (Hb), the Fe (II) is coordinated to


  • Options
  • A. four nitrogens of heme, the proximal His, and a water molecule
  • B. four nitrogens of heme and to a water molecule
  • C. two nitrogens of heme and to three His residues in Hb
  • D. two nitrogens of heme and to three water molecules

  • Correct Answer
  • four nitrogens of heme, the proximal His, and a water molecule 


  • Structure and Properties of Peptides problems


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    • 1. If the F and Y angles of each peptide unit in a protein are known, which of the following may also be determined?

    • Options
    • A. Complete secondary structure
    • B. Complete tertiary structure
    • C. Complete quaternary structure
    • D. Thermodynamic stability
    • Discuss
    • 2. The peptide, Val-Lys-Glu-Met-Ser-Trp-Arg-Ala, was digested with cyanogen bromide (CNBr) to produce:

    • Options
    • A. Val-Lys + Glu-Met-Ser + Trp-Arg-Ala
    • B. Val-Lys-Glu-Met-Ser-Trp + Arg-Ala
    • C. Val-Lys-Glu-Met + Ser-Trp-Arg-Ala
    • D. Val-Lys-Glu + Met-Ser-Trp-Arg-Ala
    • Discuss
    • 3. The Ramachandran Plot illustrates the fact that

    • Options
    • A. the peptide bond is planar
    • B. the F & Y angles can assume any value in a peptide
    • C. the F & Y angles can assume only a single value in a protein
    • D. the F & Y angles can assume approximately three different values
    • Discuss
    • 4. The molecular formula for glycine is C2H5O2N. What would be the molecular formula for a linear oligomer made by linking ten glycine molecules together by condensation synthesis?

    • Options
    • A. C20H50O20N10
    • B. C20H32O11N10
    • C. C20H40O10N10
    • D. C20H68O29N10
    • Discuss
    • 5. Disulfide bonds most often stabilize the native structure of

    • Options
    • A. extracellular proteins
    • B. dimeric proteins
    • C. hydrophobic proteins
    • D. intracellular proteins
    • Discuss
    • 6. Which hemoglobin chain replaces the beta chain in embryonic hemoglobulin?

    • Options
    • A. Delta
    • B. Epsilon
    • C. Gamma
    • D. Alfa
    • Discuss
    • 7. The major element of secondary structure in myoglobin and hemoglobin is

    • Options
    • A. the P-strand
    • B. the a-helix
    • C. the reverse turn
    • D. All of these
    • Discuss
    • 8. The heme is held in place by a bond between

    • Options
    • A. the Fe2+ and cysteine
    • B. the Fe3+ and histidine
    • C. the Fe3+ and cysteine
    • D. the Fe2+ and histidine
    • Discuss
    • 9. Which of the three subunits of the G proteins binds GDP and GTP?

    • Options
    • A. Alpha
    • B. Beta
    • C. Gamma
    • D. Delta
    • Discuss
    • 10. For the unfolding reaction of Protein G, ∆H° =210.6 kJ/mol, this means that

    • Options
    • A. unfolding is favored enthalpically
    • B. folding is favored enthalpically
    • C. the entropy is positive at all temperatures
    • D. the entropy is negative at all temperatures
    • Discuss


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