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Home Biotechnology Monoclonal Antibodies Comments

  • Question
  • In immuno-inflammatory diseases such as hemolytic anaemia, eczema etc.,


  • Options
  • A. T8 cells are greatly reduced
  • B. T8 cells are greatly increased
  • C. T4 cells are greatly reduced
  • D. T4 cells are greatly increased

  • Correct Answer
  • T8 cells are greatly reduced 


  • Monoclonal Antibodies problems


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    • 1. The approach (s), which is/are currently followed to produce human monoclonal antibodies, is/are known as

    • Options
    • A. transformation of antigen specific B lymphocytes (EBV)
    • B. hybridization of 6-thioguanine-resistant human plasmacytoma with immune human lymphocytes
    • C. combination of EB Vand hybridoma techniques
    • D. all of these
    • Discuss
    • 2. The EBV-hybridoma technique

    • Options
    • A. immortalizes the donor Bcells
    • B. facilitates the proliferation of antigen specific B cells
    • C. gives much higher hybridization frequencies
    • D. all of the above
    • Discuss
    • 3. A cytokine that stimulates the activity of B and T cells is

    • Options
    • A. lymphotoxin
    • B. interlukin-2
    • C. interlukin-1
    • D. all of these
    • Discuss
    • 4. In monoclonal antibody technology, tumor cells that can replicate endlessly are fused with mammalian cells that produce an antibody. The result of this cell fusion is a

    • Options
    • A. hybridoma
    • B. myeloma
    • C. natural killer cell
    • D. lymphoblast
    • Discuss
    • 5. The primary B cell receptor is

    • Options
    • A. IgD
    • B. IgG
    • C. IgA
    • D. IgE
    • Discuss
    • 6. The antigen-specific lymphocytes can be immortalized by which of the following method?

    • Options
    • A. Transfection with tumor derived DNA
    • B. Hybridization with a suitable lymphoid tumor cell
    • C. Transformation following infection by Epstein-Barr virus (EB V)
    • D. All of the above
    • Discuss
    • 7. It is highly valued if the lymphocytes derived from the lymph node or tonsil tend to undergo fusion at

    • Options
    • A. high frequencies
    • B. moderate frequencies
    • C. low frequencies
    • D. at no frequency
    • Discuss
    • 8. TC cells are important in controlling

    • Options
    • A. virus infections
    • B. allergy
    • C. autoimmunity
    • D. all of these
    • Discuss
    • 9. The cross linkage of antigens by antibodies is known as

    • Options
    • A. agglutination
    • B. complement fixation
    • C. a cross reaction
    • D. all of these
    • Discuss
    • 10. The Ig locus is about

    • Options
    • A. 2/3rd of all hybridomas
    • B. l/3rd of all hybridomas
    • C. l/2nd of all hybridomas
    • D. 1/4th of all hybridomas
    • Discuss


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