Monoclonal Antibodies problems
- 1. Preliminary clinical results with a humanized antibody against the interleukin-2 receptor have suggested the
Options- A. absence of human immune response against murine proteins (HAMA) response
- B. presence of HAMA response
- C. poor recognition of immunoglobulin, Ig constant regions
- D. all of the above Discuss
Correct Answer: absence of human immune response against murine proteins (HAMA) response
- 2. Which of the following is incorrect?
Options- A. MAbs can be used to diagnose or treat diseases
- B. MAbs can be used in tumor scanning
- C. MAbs canbe used in cancer diagnosis
- D. MAbs can not be used in such non-infectious diseases as those of endocrine system Discuss
Correct Answer: MAbs can not be used in such non-infectious diseases as those of endocrine system
- 3. Helper T cells assist in the functions of
Options- A. certain B cells
- B. certain T cells
- C. certain B cells and other T cells
- D. none of the above Discuss
Correct Answer: certain B cells and other T cells
- 4. The primary B cell receptor is
Options- A. IgD
- B. IgG
- C. IgA
- D. IgE Discuss
Correct Answer: IgD
- 5. In monoclonal antibody technology, tumor cells that can replicate endlessly are fused with mammalian cells that produce an antibody. The result of this cell fusion is a
Options- A. hybridoma
- B. myeloma
- C. natural killer cell
- D. lymphoblast Discuss
Correct Answer: hybridoma
- 6. A cytokine that stimulates the activity of B and T cells is
Options- A. lymphotoxin
- B. interlukin-2
- C. interlukin-1
- D. all of these Discuss
Correct Answer: interlukin-2
- 7. The EBV-hybridoma technique
Options- A. immortalizes the donor Bcells
- B. facilitates the proliferation of antigen specific B cells
- C. gives much higher hybridization frequencies
- D. all of the above Discuss
Correct Answer: all of the above
- 8. The approach (s), which is/are currently followed to produce human monoclonal antibodies, is/are known as
Options- A. transformation of antigen specific B lymphocytes (EBV)
- B. hybridization of 6-thioguanine-resistant human plasmacytoma with immune human lymphocytes
- C. combination of EB Vand hybridoma techniques
- D. all of these Discuss
Correct Answer: all of these
- 9. In immuno-inflammatory diseases such as hemolytic anaemia, eczema etc.,
Options- A. T8 cells are greatly reduced
- B. T8 cells are greatly increased
- C. T4 cells are greatly reduced
- D. T4 cells are greatly increased Discuss
Correct Answer: T8 cells are greatly reduced
- 10. The antigen-specific lymphocytes can be immortalized by which of the following method?
Options- A. Transfection with tumor derived DNA
- B. Hybridization with a suitable lymphoid tumor cell
- C. Transformation following infection by Epstein-Barr virus (EB V)
- D. All of the above Discuss
Correct Answer: All of the above
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