Self reactive antibodies are not found in significant concentration in normal se

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Question
Self reactive antibodies are not found in significant concentration in normal serum because
Options
A. it is impossible to generate a self-reactive antibody
B. self reactive B cells are killed by CD8 T cells
C. B cells that are stimulated via their surface bound antibody in the absence of T cell help to commit suicide
D. self reactive B cells switch to IgA which is all secreted and not present in serum

Correct Answer

B cells that are stimulated via their surface bound antibody in the absence of T cell help to commit suicide