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  • Question
  • Numerous antibodies can be prepared, against one antigen, each binds to unique epitopes. How is this antibody diversity generated?


  • Options
  • A. By rearrangements of the DNA encoding the variable regions of the heavy and light chains
  • B. By the combination of different heavy and light chains that form the antigen binding site
  • C. Antibody proteins can physically change their shape to bind different epitopes
  • D. Both (a) and (b)

  • Correct Answer
  • Both (a) and (b) 


  • Immune System problems


    Search Results


    • 1. Which of the following is correct for isoantigens?

    • Options
    • A. They are antigens found in all members of different species
    • B. They are antigens found in some members of a species
    • C. They are antigens found in all members of a species
    • D. They are antigens found in some members of different species
    • Discuss
    • 2. Natural killer cells are involved in

    • Options
    • A. tumour rejection
    • B. allograft rejection
    • C. non-specific killing of virus transformed target cells
    • D. all of these
    • Discuss
    • 3. What information can be generated by interrupted mating experiments?

    • Options
    • A. Levels of DNA homology
    • B. Bacterial genome maps
    • C. DNA nucleotide sequences
    • D. Proteomics of the bacteria
    • Discuss
    • 4. Which of the following transport bacterial DNA to other bacteria via bacteriophages?

    • Options
    • A. Conjugation
    • B. Transduction
    • C. Transformation
    • D. Translation
    • Discuss
    • 5. In lysogeny,

    • Options
    • A. a bacteriophage transfers bacterial DNA
    • B. bacteria take up double stranded DNA from the environment
    • C. DNA-degrading enzymes in the extracellular medium would stop the process
    • D. a bacteriophage genome is integrated into the bacterial genome
    • Discuss
    • 6. Which of the following proteins would not need localization signal?

    • Options
    • A. A nuclear protein
    • B. A cytosolic protein
    • C. A protein bound to the endoplasmic reticulum (ER) membrane
    • D. A cell surface protein
    • Discuss
    • 7. Which of the following(s) is/are the determinants of antigenicity?

    • Options
    • A. Chemical nature
    • B. Size of the antigen
    • C. Foreignness
    • D. All of these
    • Discuss
    • 8. Major Histo Compatibility Complex (MHC) is a collection of genes arrayed on

    • Options
    • A. chromosome 21 in man, chromosome 6 in mice
    • B. chromosome 6 in man, chromosone 21 in mice
    • C. chromosome 17in man, chromosome 6 in mice
    • D. chromosome 6 in man, chromosome 17 in mice
    • Discuss
    • 9. Macrophages are professional antigen- presenting cells. The protein molecule through which they present antigen in human is

    • Options
    • A. actin
    • B. interleukin
    • C. HLA
    • D. CD8
    • Discuss
    • 10. Polymorphonuclear leukocytes (or PMNs)

    • Options
    • A. can be attracted to the site of an infection following activation of complement
    • B. are derived from bone marrow stem cells
    • C. are a type of phagocyte that can engulf and kill bacteria
    • D. all of the above
    • Discuss


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