Which term describes the relationship in which a virus persists in a host cell without producing new virions, and the viral genome is replicated along with the host chromosome?

Difficulty: Easy

Correct Answer: Lysogeny

Explanation:


Introduction / Context:
Bacteriophages can follow lytic or lysogenic cycles. In lysogeny, the phage genome integrates into the bacterial chromosome as a prophage and is replicated passively with the host each cell division. Understanding lysogeny is critical for phage biology and bacterial pathogenicity (lysogenic conversion).


Given Data / Assumptions:

  • No new viral particles are produced.
  • Viral genome is replicated with the host chromosome.
  • Direct association with bacteriophage–bacterium systems.


Concept / Approach:
Lysogeny involves integration (or stable maintenance) of the phage genome and expression of repressor proteins that block lytic genes. The prophage can later be induced (e.g., by DNA damage) to enter the lytic cycle.


Step-by-Step Solution:

1) Match features (no virion production, genome co-replication) to phage life cycles.2) Identify lysogeny as the only option matching both features.3) Select “Lysogeny.”


Verification / Alternative check:
Classic lambda phage model: cI repressor maintains lysogeny; induction leads to lytic replication.


Why Other Options Are Wrong:

  • Lysis: Involves active virion production and cell rupture.
  • Transformation/Conjugation: Horizontal gene transfer between bacteria; unrelated to phage persistence.


Common Pitfalls:

  • Equating lysogeny with generalized transduction; they are distinct processes.
  • Assuming all integrated elements immediately produce virions—lysogeny is dormant.


Final Answer:
Lysogeny

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