In the lysogenic cycle of a bacteriophage, which statement correctly describes the state of the phage genome with respect to the bacterial host?

Difficulty: Easy

Correct Answer: A bacteriophage genome is integrated into the bacterial genome

Explanation:


Introduction / Context:
Lysogeny is a dormant relationship between a bacteriophage and its bacterial host. Instead of producing new virions immediately, the phage genome becomes a prophage integrated into the host chromosome and is replicated with the host. This concept underpins lysogenic conversion and prophage induction.


Given Data / Assumptions:

  • We focus on the state of the phage genome during lysogeny.
  • No lytic replication occurs during stable maintenance.


Concept / Approach:
In lysogeny, integration is mediated by phage integrase and host recombination systems. A repressor protein keeps lytic genes inactive. Environmental stress (e.g., DNA damage) can trigger induction to the lytic cycle.


Step-by-Step Solution:

1) Identify that lysogeny ≠ active phage production.2) Recognize that the hallmark is chromosomal integration of the phage genome (prophage).3) Select the option describing integration into the bacterial genome.


Verification / Alternative check:
Lambda phage lysogeny model (cI repressor, att sites) is the classic proof.


Why Other Options Are Wrong:

  • Phage transfers bacterial DNA: That is generalized or specialized transduction, not lysogeny itself.
  • Bacteria take up dsDNA from environment: Transformation, not lysogeny.
  • Extracellular DNases stop the process: Relevant to transformation, not to integrated prophage maintenance.


Common Pitfalls:

  • Mixing up transduction (DNA transfer by phage particles) with the dormancy of lysogeny.


Final Answer:
A bacteriophage genome is integrated into the bacterial genome

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