Helical capsid example: which bacteriophage is a rod-shaped filament with capsomeres arranged helically rather than in stacked rings?
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ABateriophage M13
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BBateriophage MV-L2
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CBateriophage T2
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DBateriophage T4
Answer
Correct Answer: Bateriophage M13
Explanation
Introduction / Context: Virus capsid symmetry is commonly icosahedral or helical. Filamentous bacteriophages are classic examples of helical symmetry, where identical capsid subunits wrap around the nucleic acid to form a rod-like particle. Recognizing exemplars helps connect morphology to life cycle and applications (for example, phage display).
Given Data / Assumptions:
- Rod-shaped viruses with helical symmetry have capsomeres arranged in a helix along the genome.
- T-even phages (T2, T4) are tailed, complex icosahedral heads, not simple helical rods.
- M13 is a filamentous (Ff) phage infecting E. coli bearing F pili.
Concept / Approach: M13’s coat protein subunits polymerize around circular single-stranded DNA to form a flexible filament with helical symmetry. In contrast, T2/T4 possess icosahedral heads and contractile tails; their capsid proteins form facets, not continuous helices around the genome. Therefore, the correct helical rod example among the choices is M13.
Step-by-Step Solution:
Identify capsid symmetries: helical vs icosahedral vs complex.Match candidates: T2/T4 → complex (icosahedral head + tail); M13 → filamentous helical rod.Exclude MV-L2 (not a standard textbook exemplar).Select M13 as the canonical helical rod-shaped phage.Verification / Alternative check: Structural images and cryo-EM reconstructions show M13 as a long filament with helical arrangement of coat proteins.
Why Other Options Are Wrong:
- Bacteriophage T2/T4: Complex morphology; not helical rods.
- MV-L2: Not the classic rod-shaped helical example compared with M13.
Common Pitfalls: Confusing “helical symmetry” with “stacked ring” descriptions of some rod-like viruses; assuming all bacteriophages are tailed and icosahedral.
Final Answer: Bateriophage M13