Enzymes and Kinetics problems
- 1. The rate-determining step of Michaelis Menten kinetics is
Options- A. the complex formation step
- B. the complex dissociation step to produce product
- C. the product formation step
- D. Both (a)and(c) Discuss
Correct Answer: the complex dissociation step to produce product
- 2. The active site of an enzyme remains
Options- A. at the center of globular proteins
- B. rigid and does not change shape
- C. complementary to the rest of the molecule
- D. none of the above Discuss
Correct Answer: none of the above
- 3. In a Lineweaver-Burk Plot, competitive inhibitor shows which of the following effect?
Options- A. It moves the entire curve to right
- B. It moves the entire curve to left
- C. It changes the x-intercept
- D. It has no effect on the slope Discuss
Correct Answer: It changes the x-intercept
- 4. The enzyme inhibition can occur by
Options- A. reversible inhibitors
- B. irreversible inhibitors
- C. Both (a) and (b)
- D. None of these Discuss
Correct Answer: Both (a) and (b)
- 5. Which graphical method is used to determine an enzyme degree of cooperativity?
Options- A. Hill plot
- B. Koshland curve
- C. Michaelis-Menten hyperbola
- D. Can not be determined Discuss
Correct Answer: Hill plot
- 6. Which of these enzymes contains a Zinc (Zn) ion?
Options- A. Carboxypeptidase A
- B. Phosphorylase B kinase
- C. Tyrosine hydroxylase
- D. Phosphodiesterase Discuss
Correct Answer: Carboxypeptidase A
- 7. Non-competitive inhibitor of an enzyme catalyzed reaction
Options- A. decreases Vmax
- B. binds to Michaelis complex (ES)
- C. both (a) and (b)
- D. can actually increase reaction velocity in rare cases Discuss
Correct Answer: both (a) and (b)
- 8. The effect of non-competitive inhibition on a Lineweaver-Burk Plot is that
Options- A. it can move the entire curve to the right
- B. it can change the y-intercept
- C. it can change the x-intercept
- D. all of these Discuss
Correct Answer: it can change the y-intercept
- 9. Which category of enzymes belongs to class two in the international classification?
Options- A. Hydrolases
- B. Ligases
- C. Transferases
- D. Isomerase Discuss
Correct Answer: Transferases
- 10. Given an enzyme with a Km = 10m M and Vmax = 100 m mol/min. If [S] = 100 m M, which of the following will be true?
Options- A. A 10 fold increase in Vmax would increase velocity 10 fold y
- B. A 10 fold decrease in Km would increase velocity
- C. Both (a) and (b)
- D. A 10 fold increase in Vmax would decrease velocity 20 fold Discuss
Correct Answer: A 10 fold increase in Vmax would increase velocity 10 fold y
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