Hematology and minerals — Which mineral specifically aids the utilization of iron and supports hemoglobin synthesis in humans?

Introduction / Context:
Copper is a critical trace element in iron metabolism. Multiple cuproenzymes support iron transport and hemoglobin synthesis, and copper deficiency can present with anemia resembling iron deficiency that is unresponsive to iron alone. This question targets recognition of copper’s enabling role in iron utilization.

Given Data / Assumptions:

• Hephaestin (intestinal) and ceruloplasmin (plasma) are copper-dependent ferroxidases.
• Ferroxidases oxidize Fe2+ to Fe3+ to load transferrin efficiently.
• Effective iron delivery to the marrow is necessary for hemoglobin synthesis.

Concept / Approach:
Identify the mineral that functions through ferroxidases and transport proteins to mobilize iron. Copper deficiency impairs iron export from enterocytes and delivery to transferrin, reducing availability for erythropoiesis. Hence, copper is the correct choice.

Step-by-Step Solution:

Verification / Alternative check:
Clinical copper deficiency (e.g., in malabsorption) causes microcytic, hypochromic anemia that corrects with copper repletion.

Why Other Options Are Wrong:

Common Pitfalls:
Assuming all trace metals enhance iron absorption; copper is uniquely essential via ferroxidase activity.

Final Answer:
Copper.