Difficulty: Easy
Correct Answer: Distribute shear throughout the reactor and minimise bubble coalescence
Explanation:
Introduction / Context:
In airlift fermenters, a draft tube delineates riser and downcomer flows and shapes circulation patterns. Proper design improves gas holdup distribution, reduces large eddies, and provides a gentle environment for shear-sensitive cultures while sustaining effective mass transfer.
Given Data / Assumptions:
Concept / Approach:
By organizing circulation, the draft tube spreads velocity gradients, reducing hotspots of shear. Better distribution of bubbles lengthens residence time and suppresses coalescence, sustaining small bubble sizes and larger interfacial area, which enhances kLa without excessive mechanical stress.
Step-by-Step Solution:
Verification / Alternative check:
Tracer and PIV studies show improved circulation uniformity with draft tubes versus bare columns, correlating with higher oxygen transfer efficiency at similar gas rates.
Why Other Options Are Wrong:
Common Pitfalls:
Confusing chemical solubility limits with hydrodynamic mass transfer; assuming more shear always improves kLa regardless of cell sensitivity.
Final Answer:
Distribute shear throughout the reactor and minimise bubble coalescence
Discussion & Comments