Viral replication sequence: Identify the correct chronological order of events in a typical productive viral replication cycle.

Difficulty: Easy

Correct Answer: Attachment, penetration, biosynthesis, maturation, release

Explanation:


Introduction / Context:
Although the details vary among DNA and RNA viruses, the core sequence of a lytic replication cycle follows a consistent logic from host recognition to progeny exit.



Given Data / Assumptions:

  • Attachment (adsorption) precedes entry.
  • Penetration and uncoating allow genome access to host machinery.
  • Biosynthesis of nucleic acids and proteins precedes assembly (maturation).
  • Release occurs last, by lysis or budding.



Concept / Approach:
Think causally: you cannot synthesize viral components prior to entry, and you cannot release before assembly. Therefore the sequence is attachment → penetration (and uncoating) → biosynthesis → maturation (assembly) → release.



Step-by-Step Solution:
Start with attachment to host receptors. Proceed to penetration and uncoating to free the genome. Perform biosynthesis of viral RNA/DNA and proteins. Assemble capsids and package genomes (maturation). Exit the cell via lysis or budding (release).



Verification / Alternative check:
Textbook schematics for bacteriophages and animal viruses present this same order, differing mainly in entry and release mechanisms.



Why Other Options Are Wrong:
Sequences that put release or maturation before biosynthesis violate causality; sporulation is a bacterial process, not viral.



Common Pitfalls:
Forgetting uncoating is part of the early entry phase and mixing up assembly with synthesis.



Final Answer:
Attachment, penetration, biosynthesis, maturation, release.


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