In human botulism, which toxin types of Clostridium botulinum are most commonly implicated? Select the best aggregate option reflecting the major types causing disease in adults and infants.

Introduction:
Clostridium botulinum produces several antigenically distinct neurotoxin types (A–G). Understanding which types predominate in human disease is fundamental for epidemiology, clinical suspicion, and antitoxin selection.

Given Data / Assumptions:

• Focus on toxin types commonly linked to human botulism.
• Choices list A, B, and E individually and as a combined “All of these.”
• No geographic microdetail is required.

Concept / Approach:
Worldwide, toxin types A, B, and E account for the majority of foodborne and infant botulism cases. Type E is classically associated with fish and marine products; Types A and B are more common in terrestrial foods and soil-contaminated sources.

Step-by-Step Solution:
Step 1: Recall the human-disease–associated toxin spectrum. Step 2: Recognize A, B, and E as the principal culprits. Step 3: Select “All of these” to cover A, B, and E together.

Verification / Alternative check:
Outbreak catalogs and reference manuals consistently list types A, B, and E as responsible for the overwhelming majority of human cases; types C and D are classically veterinary, and F is rare in humans.

Why Other Options Are Wrong:
Type A – true but incomplete.
Type B – true but incomplete.
Type E – true but incomplete.
Type F only – rare and not the predominant human type.

Common Pitfalls:
Assuming a single type dominates worldwide; distribution varies by region and commodity, but A, B, and E together cover most cases.

Final Answer:
All of these.