Selective permeability of the plasma membrane The barrier properties of the plasma membrane depend primarily on the presence of which feature?

Biochemistry Membrane Structure and Functions Difficulty: Easy
Choose an option
  • A
    Specific transport proteins
  • B
    Free amino acids embedded in the bilayer
  • C
    Carbohydrates alone on the outer leaflet
  • D
    None of these
  • E
    DNA threads attached to the cytosolic face

Answer

Correct Answer: Specific transport proteins

Explanation

Introduction / Context:Cells must regulate what enters and leaves. The lipid bilayer provides a hydrophobic barrier, but selectivity and controlled rates come from protein transport systems embedded in the membrane.

Given Data / Assumptions:

  • Lipids form a barrier to polar and charged solutes.
  • Transport proteins allow regulated passage of ions and molecules.
  • Carbohydrates are involved mainly in recognition, not translocation.

Concept / Approach:Selective permeability emerges from channels, carriers, and pumps—each an integral protein with substrate specificity and gating/regulatory features. This contrasts with nonselective diffusion of hydrophobic solutes through lipids.

Step-by-Step Solution:Identify the need: selectivity and regulation.Associate with mechanism: specific transport proteins (ion channels, uniporters, symporters, antiporters, ATPases).Eliminate options lacking transmembrane transport capabilities.

Verification / Alternative check:Patch-clamp and transporter kinetics demonstrate substrate-specific conductance and saturable transport, respectively.

Why Other Options Are Wrong:

  • Amino acids / DNA: Not structural transport elements.
  • Carbohydrates: Key for cell–cell recognition but not for solute translocation.

Common Pitfalls:Assuming the lipid bilayer alone confers selectivity; it mainly restricts polar solutes without specificity.

Final Answer:Specific transport proteins.

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