Chemical nature of membrane lipids Membrane lipids are best described as what kind of molecules?

Difficulty: Easy

Correct Answer: Amphipathic (amphiphilic) molecules

Explanation:


Introduction / Context:
Phospholipids, glycolipids, and sterols collectively form biological membranes. Their amphipathic character explains spontaneous bilayer formation and many membrane properties.



Given Data / Assumptions:

  • Lipids contain polar headgroups and nonpolar hydrocarbon tails (or ring systems for sterols with a polar OH).
  • Aqueous environments drive self-assembly via the hydrophobic effect.



Concept / Approach:
Amphipathic molecules possess both hydrophilic and hydrophobic parts. In water, they minimize free energy by burying nonpolar regions away from water while exposing polar headgroups, forming micelles or bilayers. This duality is indispensable for membrane integrity and protein insertion.



Step-by-Step Solution:
Identify the polar component: phosphate-containing or sugar headgroups; cholesterol –OH.Identify the nonpolar component: fatty acyl chains or steroid rings + tail.Conclude that membrane lipids are amphipathic (amphiphilic).



Verification / Alternative check:
Vesicle formation in vitro (liposomes) and phase transitions confirm amphipathic behavior.



Why Other Options Are Wrong:

  • Hydrophilic only / hydrophobic only: Cannot explain bilayer formation.
  • Charged polymers: Describe nucleic acids, not membrane lipids.



Common Pitfalls:
Confusing amphipathic (two natures) with amphoteric (acid/base); they are different concepts.



Final Answer:
Amphipathic (amphiphilic) molecules.


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