Fluid mosaic model—dimensionality and composition According to the fluid mosaic model, a biological membrane is best described as:
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AA two-dimensional solution of oriented lipids with interspersed globular proteins
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BA three-dimensional solution of oriented lipids and globular proteins
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CA two-dimensional solution of oriented lipids and carbohydrates only
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DA three-dimensional network dominated by carbohydrates
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EA rigid crystalline lattice of lipids without protein movement
Answer
Correct Answer: A two-dimensional solution of oriented lipids with interspersed globular proteins
Explanation
Introduction / Context:The fluid mosaic model unifies how lipids and proteins are arranged and move within membranes, explaining selective permeability, lateral diffusion, and dynamic organization.
Given Data / Assumptions:
- Membranes are lipid bilayers with embedded proteins.
- Lipids and many proteins diffuse laterally (2D fluid).
- Carbohydrates decorate proteins and lipids extracellularly but do not dominate structure.
Concept / Approach:“Two-dimensional solution” emphasizes lateral mobility within the plane of the bilayer. Proteins are mosaically distributed and can drift or be corralled, while lipids provide a continuous matrix. Vertical (3D) diffusion across the bilayer is restricted.
Step-by-Step Solution:Identify the dimensionality of primary diffusion: two-dimensional.Recall composition: oriented lipids form the bilayer; globular proteins are embedded and peripheral.Select the option that matches these features.
Verification / Alternative check:FRAP experiments demonstrate lateral diffusion, supporting the 2D fluid paradigm.
Why Other Options Are Wrong:
- 3D solutions: Misstate the dominant lateral dynamics.
- Carbohydrate-only models: Ignore integral proteins and lipids.
- Rigid lattice: Inconsistent with fluidity observed experimentally.
Common Pitfalls:Assuming proteins are static or evenly distributed; microdomains and fences influence mobility.
Final Answer:A two-dimensional solution of oriented lipids with interspersed globular proteins.