In DNA replication theory, which hypothesis proposes that parental DNA is broken into fragments and each daughter molecule contains interspersed mixtures of old and new DNA throughout both strands?

Biochemistry DNA Structure and Replication Difficulty: Easy
Choose an option
  • A
    Conservative theory
  • B
    Dispersive theory
  • C
    Semi-conservative theory
  • D
    Evolutionary theory

Answer

Correct Answer: Dispersive theory

Explanation

Introduction / Context:Before the Meselson–Stahl experiment, multiple models were proposed for how DNA duplicates. This question distinguishes among conservative, semi-conservative, and dispersive replication models.

Given Data / Assumptions:

  • The hypothesis described says parental DNA is fragmented.
  • Daughter DNA strands are mosaics: both strands contain alternating old and new segments.

Concept / Approach:Match the described mosaic pattern to the formal model names. The dispersive model uniquely predicts mixed old/new DNA along both strands after each round.

Step-by-Step Solution:1) Conservative: parental duplex remains intact; a wholly new duplex is made. Not a mosaic.2) Semi-conservative: each daughter duplex has one old strand and one new strand; strands are not internally mixed.3) Dispersive: both strands in daughters consist of interspersed old and new DNA fragments, matching the description.

Verification / Alternative check:Meselson–Stahl density data excluded pure conservative after one generation and later excluded dispersive due to observed strand patterns after additional generations and nicking/denaturation tests.

Why Other Options Are Wrong:Conservative and semi-conservative do not predict internal mixing of old/new along the same strand; “evolutionary theory” is not a DNA replication model.

Common Pitfalls:Confusing “semi-conservative” (one old + one new strand) with “dispersive” (mosaic within each strand).

Final Answer:Dispersive theory

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