Chromatin higher-order structure: a ~30 nm fiber in which each helical turn contains about five to six nucleosomes is called what?

Difficulty: Easy

Correct Answer: Solenoid

Explanation:


Introduction / Context:
Eukaryotic DNA wraps around histone octamers to form nucleosomes (~10–11 nm fiber). These units can pack into higher-order fibers near ~30 nm diameter. One classic model with five to six nucleosomes per helical turn is the solenoid model. This question checks recognition of that terminology within chromatin organization.


Given Data / Assumptions:

  • Fiber diameter is approximately 30 nm.
  • Each helical turn contains roughly five to six nucleosomes.
  • Asks for the conventional name of this arrangement.


Concept / Approach:
Two principal 30 nm packing models are described: the solenoid (one-start helix with bent linker DNA) and the zigzag/two-start model (straighter linker DNA crossing the fiber). The stem specifies five to six nucleosomes per helical turn, aligning with the solenoid description.


Step-by-Step Solution:

1) Identify fiber diameter: ~30 nm indicates higher-order nucleosome packing.2) Note given stoichiometry: five to six nucleosomes per turn.3) Map to canonical models: these details match the solenoid model.4) Conclude the correct term is “Solenoid”.


Verification / Alternative check:
Texts often contrast solenoid vs zigzag. The “five to six nucleosomes per turn” cue specifically signals the solenoid arrangement.


Why Other Options Are Wrong:

  • Halonoid: not a standard chromatin fiber term.
  • Kinetoplast: a mitochondrial DNA network in kinetoplastids, unrelated to nucleosomal fibers.
  • None of these: incorrect because a standard term exists.
  • Zigzag two-start fiber: alternative model, but the turn/packing cue favors solenoid.


Common Pitfalls:
Assuming all 30 nm fibers are identical; in reality, multiple packing modes may exist and depend on ionic conditions and linker histone presence. Here, the numeric cue resolves the correct term.


Final Answer:
Solenoid

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