Which of the following hepatitis viruses is NOT an RNA virus? (Identify the DNA virus among common hepatitis agents.)
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AHepatitis A virus
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BHepatitis B virus
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CHepatitis E virus
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DHepatitis G virus
Answer
Correct Answer: Hepatitis B virus
Explanation
Introduction: Most hepatitis viruses are RNA viruses, but one major exception exists. This question tests recognition of the unique nucleic acid type that distinguishes hepatitis B virus (HBV) from other hepatitis agents.
Given Data / Assumptions:
- HAV, HEV, and HGV (GB virus C) are RNA viruses.
- HBV belongs to the Hepadnaviridae family and possesses DNA.
- Classification is based on genome type, not clinical syndrome severity.
Concept / Approach: HBV contains a partially double-stranded, circular DNA genome and replicates via reverse transcription. In contrast, HAV (Picornaviridae), HEV (Hepeviridae), and HGV/GBV-C (Flaviviridae-related) carry single-stranded RNA genomes.
Step-by-Step Solution: List genome types for each candidate. Single out the DNA-containing virus (HBV). Confirm others are RNA viruses. Choose the only non-RNA option.
Verification / Alternative check: Standard virology references classify HBV as a DNA virus with reverse transcriptase activity.
Why Other Options Are Wrong:
- Hepatitis A / E / G: All are RNA viruses.
Common Pitfalls: Confusing replication via reverse transcriptase (seen in HBV) with RNA genome possession; HBV is still a DNA virus.
Final Answer: Hepatitis B virus is not an RNA virus.