Functional role of the positive strand in dsRNA viruses: Among the two strands, what is the primary function served by the positive-sense RNA inside host cells?

Difficulty: Easy

Correct Answer: Synthesis of protein

Explanation:


Introduction / Context:
Viral replication depends on converting genetic information into proteins. For dsRNA viruses, understanding which strand can act directly in translation clarifies early steps of infection.



Given Data / Assumptions:

  • Genome is double-stranded RNA.
  • One strand is positive-sense (same polarity as mRNA).
  • We seek the function of that positive strand.



Concept / Approach:
The positive-sense RNA strand corresponds to mRNA. When accessible, it can be translated by host ribosomes to produce viral proteins. Ribosomes themselves are complex ribonucleoprotein machines assembled by the cell; viruses do not produce ribosomes de novo.



Step-by-Step Solution:
Define positive-sense RNA: has the same polarity as mRNA. Translation: ribosomes read mRNA to synthesize proteins. Apply to dsRNA viruses: the + strand serves as the coding template for protein synthesis once separated. Therefore, its function is protein synthesis, not ribosome production.



Verification / Alternative check:
In vitro translation of purified +RNA generates viral proteins; ribosome biogenesis uses host nucleolar pathways, independent of viral RNA sense.



Why Other Options Are Wrong:

  • Production of ribosomes: a host nuclear/nucleolar process; viruses do not encode complete ribosome assembly.
  • Both (a) and (b): incorrect because only (a) applies.
  • None of these: incorrect because (a) is true.



Common Pitfalls:
Assuming any viral RNA can create cellular organelles; viral RNAs program protein synthesis, not organelle biogenesis.



Final Answer:
Synthesis of protein

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