Citric acid cycle connections — What do coenzyme A, carbon dioxide (CO2), oxaloacetate (OAA), and FADH2 have in common in core metabolism?

Difficulty: Easy

Correct Answer: They are all components or products of the citric acid (Krebs) cycle

Explanation:


Introduction / Context:
The citric acid cycle is a central metabolic hub. CoA forms acetyl-CoA to enter the cycle, CO2 is released during decarboxylation steps, oxaloacetate is both the starting and ending four-carbon acceptor, and FADH2 is a reduced cofactor produced at succinate dehydrogenase (Complex II).


Given Data / Assumptions:

  • Acetyl-CoA condenses with OAA to form citrate.
  • CO2 is produced at isocitrate dehydrogenase and alpha-ketoglutarate dehydrogenase steps.
  • FAD is reduced to FADH2 when succinate is oxidized to fumarate.


Concept / Approach:
Relate each item to a specific TCA step to confirm their commonality with the Krebs cycle.


Step-by-Step Solution:

CoA → part of acetyl-CoA entry to the cycle.CO2 → product of oxidative decarboxylations.OAA → regenerated acceptor closing the cycle.FADH2 → produced at succinate dehydrogenase, feeding electrons to the ETC.


Verification / Alternative check:
Standard biochemical maps show these roles explicitly in the TCA cycle scheme.


Why Other Options Are Wrong:

b) Dark reactions use CO2 and NADPH; CoA and FADH2 are not Calvin cycle components.c) Lactic fermentation mainly involves pyruvate ↔ lactate and NADH ↔ NAD+.d) FADH2 participates in oxidative phosphorylation after being generated in the TCA cycle.e) The TCA cycle operates in both prokaryotes and eukaryotes.


Common Pitfalls:
Separating TCA from oxidative phosphorylation; they are linked via NADH/FADH2 supply.


Final Answer:
They are all components or products of the citric acid cycle.

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