Difficulty: Easy
Correct Answer: Nonsense codons
Explanation:
Introduction / Context:
Protein synthesis terminates when the ribosome encounters specific triplets that do not encode an amino acid. These signals recruit release factors, triggering hydrolysis of the peptidyl–tRNA bond and disassembly of the translation complex.
Given Data / Assumptions:
Concept / Approach:
Historically, ‘‘nonsense codon’’ denotes a triplet that does not specify an amino acid (in contrast to ‘‘sense’’ codons). In bacteria, RF1 recognizes UAA/UAG; RF2 recognizes UAA/UGA; in eukaryotes, eRF1 recognizes all three. Specialized contexts (selenocysteine incorporation at UGA with SECIS) are regulated exceptions, not the rule.
Step-by-Step Solution:
Identify the collective term for stop codons: nonsense codons.Recall the three canonical triplets: UAA, UAG, UGA.Select the appropriate option.
Verification / Alternative check:
Mutations converting a sense codon to UAA/UAG/UGA cause premature termination (nonsense mutation), demonstrating the functional meaning of ‘‘nonsense’’ in genetics.
Why Other Options Are Wrong:
Common Pitfalls:
Confusing ‘‘nonsense’’ (stop) with ‘‘missense’’ (amino acid substitution); they have distinct phenotypic outcomes.
Final Answer:
Nonsense codons
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