Choose the correct definition: What is a mutagen in the context of molecular genetics and microbiology?

Difficulty: Easy

Correct Answer: a chemical or physical agent that induces mutations

Explanation:


Introduction / Context:
Mutagens are central to understanding mutational processes in cells, from environmental exposures to laboratory mutagenesis. Correctly defining a mutagen helps distinguish it from repair enzymes, stabilizers, or regulatory inhibitors, and informs safety practices and experimental design.


Given Data / Assumptions:

  • Mutations are heritable DNA sequence changes.
  • External agents can increase mutation frequency above the spontaneous rate.
  • Agents can be physical (for example, UV light) or chemical (for example, alkylating compounds).


Concept / Approach:
A mutagen is any physical or chemical agent that elevates the rate of mutation by damaging DNA or interfering with replication fidelity. Examples include ultraviolet radiation causing pyrimidine dimers, ionizing radiation causing breaks, and chemicals such as ethyl methanesulfonate introducing alkyl groups that mispair during replication.


Step-by-Step Solution:
Identify the action: induces or increases mutations. Specify agent types: physical and chemical are both included. Select the option matching this definition precisely. Reject options describing repair or stabilization functions.


Verification / Alternative check:
Ames test screens chemicals for mutagenicity by measuring reversion rates in reporter strains, demonstrating the operational definition of mutagens.


Why Other Options Are Wrong:

  • Enzyme that repairs mutations: describes repair proteins, not mutagens.
  • Inhibitor of gene modification: unrelated to induction of mutations.
  • DNA stabilizer: opposite effect, reducing mutation likelihood.


Common Pitfalls:
Assuming only chemicals are mutagens; physical agents also qualify and can be potent.


Final Answer:
a chemical or physical agent that induces mutations

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