During which fundamental process is an exact new copy of a DNA molecule synthesized?

Difficulty: Easy

Correct Answer: Replication (DNA-directed DNA synthesis)

Explanation:


Introduction / Context:
Central dogma steps—replication, transcription, and translation—have distinct information flows. Only one process duplicates the genetic material itself to pass to daughter cells: replication.


Given Data / Assumptions:

  • The question asks about producing a precise, complementary copy of a DNA molecule.
  • Other listed processes relate to RNA synthesis, protein synthesis, or DNA exchange.


Concept / Approach:
Replication is semi-conservative: each daughter duplex contains one parental and one newly synthesized strand. DNA polymerases copy templates in the 5′→3′ direction using primers. Transcription produces RNA, translation produces polypeptides, transformation and recombination alter DNA content but do not copy the entire DNA molecule as a dedicated process.


Step-by-Step Solution:
Define “exact new copy” as duplication of the DNA duplex.Identify the enzymatic process that accomplishes this: DNA replication.Exclude transcription (DNA→RNA), translation (RNA→protein), and transformation/recombination (DNA movement/reshuffling).


Verification / Alternative check:
Meselson–Stahl experiments demonstrated semi-conservative replication using isotope labeling of DNA strands, directly confirming the mechanism.


Why Other Options Are Wrong:

  • Transformation: introduces external DNA but does not copy the entire genome.
  • Transcription: creates RNA, not DNA.
  • Translation: uses mRNA to build proteins.
  • Recombination: rearranges DNA segments, not wholesale duplication.


Common Pitfalls:
Equating “trans” words (transcription/translation/transformation) with duplication; only replication duplicates DNA.


Final Answer:
Replication (DNA-directed DNA synthesis)

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