Question 1

The Hill coefficient (nH) for myoglobin and hemoglobin are respectively

Accepted Answer

1.0 and 2.8

Question 2

An allosteric activator

Accepted Answer

both (a) and (c)

Question 3

The conformational changes from the T to the R state is initiated by

Accepted Answer

binding of oxygen to the heme

Question 4

When protein binds two ligands in a non-cooperative manner, then the x-intercept of the Scatchard Plot is

Accepted Answer

2

Question 5

The specificity of a ligand binding site on a protein is based on

Accepted Answer

the amino acid residues lining the binding site

Question 6

A protein that binds two ligands in a non-cooperative manner will show

Accepted Answer

both (b) and (c)

Question 7

O2 binding to hemoglobin results in

Accepted Answer

both (a) and (b)

Question 8

In hemoglobin, allosteric effects occur

Accepted Answer

to maximize oxygen delivery to the tissues

Question 9

Bisphosphoglycerate (BPG) cannot bind to the oxygenated R state of hemoglobin because

Accepted Answer

its binding pocket becomes too small to accommodate BPG

Question 10

Small molecules affect hemoglobin (Hb) by

Accepted Answer

increasing [H+] and decreasing Hb affinity for O2

Question 11

A protein that shows infinite cooperative for binding of n ligands will

Accepted Answer

both (b) and (c)

Allosteric Effects Questions