In how many different ways can the letters of the word 'THERAPY' be arranged so that the vowels never come together?

Given word is THERAPY.

Number of letters in the given word = 7

These 7 letters can be arranged in 7! ways.

Number of vowels in the given word = 2 (E, A)

The number of ways of arrangement in which vowels come together is 6! x 2! ways

Hence, the required number of ways can the letters of the word 'THERAPY' be arranged so that the vowels never come together = 7! - (6! x 2!) ways = 5040 - 1440 = 3600 ways.