Terminology check: the active form of an enzyme that includes its protein part and any required cofactor is called the:
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Aapoenzyme
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Bcoenzyme
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Choloenzyme
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Dnone of these
Answer
Correct Answer: holoenzyme
Explanation
Introduction / Context:Many enzymes require non-protein components to function. These may be metal ions or organic coenzymes. The combined active complex has a specific name that distinguishes it from the protein portion alone.
Given Data / Assumptions:
- A protein portion (apoenzyme) may be inactive by itself.
- Cofactors can be metal ions or organic molecules (coenzymes or prosthetic groups).
- The active catalytic entity includes both parts.
Concept / Approach:The holoenzyme is the complete, catalytically active enzyme comprising the apoenzyme plus its necessary cofactor(s). The apoenzyme alone lacks full catalytic activity. A coenzyme is the organic cofactor component and is not the complete catalytic complex by itself.
Step-by-Step Solution:
Define components: apoenzyme (protein) + cofactor.Name the active sum: holoenzyme.Select “holoenzyme.”Verification / Alternative check:Enzyme assays often show no activity until cofactors are supplied, confirming that only the holoenzyme is catalytically competent.
Why Other Options Are Wrong:Apoenzyme: Protein alone, typically inactive. Coenzyme: Organic cofactor only, not the full catalytic entity. None of these: Incorrect because the proper term exists.
Common Pitfalls:Using “coenzyme” and “cofactor” interchangeably with “holoenzyme”; remember holoenzyme refers to the complete active complex.
Final Answer:holoenzyme