Essential RNAs for translation — which molecules are required? During protein synthesis in cells, which of the following RNA types are required for the process to proceed?
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AtRNA (transfer RNA) only
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BmRNA (messenger RNA) only
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CrRNA (ribosomal RNA) only
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DAll of these (tRNA, mRNA, and rRNA)
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EsnRNA (small nuclear RNA) only
Answer
Correct Answer: All of these (tRNA, mRNA, and rRNA)
Explanation
Introduction:Translation converts genetic information into protein. Three RNA types play indispensable roles: mRNA carries the codon template, tRNA delivers amino acids via anticodons, and rRNA forms the structural and catalytic core of the ribosome.
Given Data / Assumptions:
- mRNA encodes the amino acid sequence via codons.
- tRNA acts as an adaptor linking codons to amino acids.
- rRNA provides both scaffold and catalytic peptidyl transferase activity.
Concept / Approach:
Because each RNA type fulfills a nonredundant function, translation requires all three simultaneously. Removing any one stalls the process: without mRNA there is no template, without tRNA there is no delivery, and without rRNA there is no ribosome or catalysis.
Step-by-Step Solution:
mRNA binds the small subunit and defines the reading frame.tRNAs decode codons and carry amino acids to the A site.rRNA in the large subunit catalyzes peptide bond formation, extending the chain.The cycle repeats codon by codon until termination.Verification / Alternative check:
Depletion or inhibition of any of these RNA classes halts translation in vivo and in vitro, demonstrating their essentiality.
Why Other Options Are Wrong:
Each single-RNA option omits required partners; snRNA participates mainly in pre-mRNA splicing, not cytosolic translation.
Common Pitfalls:
Assuming ribosomal proteins, rather than rRNA, provide the principal catalytic activity.
Final Answer:
All of these (tRNA, mRNA, and rRNA)