Definition check: A nucleoside is best described as a purine or pyrimidine base that is __________ to a pentose sugar.

Difficulty: Easy

Correct Answer: covalently bonded

Explanation:


Introduction / Context:
Precise terminology—nucleoside versus nucleotide—is foundational in biochemistry. Mislabeling can cause confusion in pathways like salvage, phosphorylation, and nucleic acid synthesis.



Given Data / Assumptions:

  • Nucleoside = base + sugar.
  • Nucleotide = nucleoside + phosphate group(s).
  • Bond type between base and sugar is asked.



Concept / Approach:
A nucleoside has a nitrogenous base linked to a pentose sugar via a covalent N-glycosidic bond (N9 of purines or N1 of pyrimidines to C1' of the sugar). Ionic or hydrogen bonds do not define the core nucleoside linkage.



Step-by-Step Solution:
Identify components: base + sugar.Recall linkage: N-glycosidic covalent bond.Therefore, “covalently bonded” is correct.



Verification / Alternative check:
Hydrolysis under acidic conditions cleaves the glycosidic bond—consistent with a covalent linkage.



Why Other Options Are Wrong:

  • Ionic and hydrogen bonds are noncovalent and do not define nucleosides.
  • “None of the above” is incorrect because the covalent option is valid.



Common Pitfalls:
Confusing nucleosides with nucleotides (which include phosphate).



Final Answer:
covalently bonded

More Questions from Nucleic Acids

Discussion & Comments

No comments yet. Be the first to comment!
Join Discussion