In DNA replication theory, which hypothesis proposes that parental DNA is broken into fragments and each daughter molecule contains interspersed mixtures of old and new DNA throughout both strands?

Difficulty: Easy

Correct Answer: Dispersive theory

Explanation:


Introduction / Context:
Before the Meselson–Stahl experiment, multiple models were proposed for how DNA duplicates. This question distinguishes among conservative, semi-conservative, and dispersive replication models.


Given Data / Assumptions:

  • The hypothesis described says parental DNA is fragmented.
  • Daughter DNA strands are mosaics: both strands contain alternating old and new segments.


Concept / Approach:
Match the described mosaic pattern to the formal model names. The dispersive model uniquely predicts mixed old/new DNA along both strands after each round.


Step-by-Step Solution:
1) Conservative: parental duplex remains intact; a wholly new duplex is made. Not a mosaic.2) Semi-conservative: each daughter duplex has one old strand and one new strand; strands are not internally mixed.3) Dispersive: both strands in daughters consist of interspersed old and new DNA fragments, matching the description.


Verification / Alternative check:
Meselson–Stahl density data excluded pure conservative after one generation and later excluded dispersive due to observed strand patterns after additional generations and nicking/denaturation tests.


Why Other Options Are Wrong:
Conservative and semi-conservative do not predict internal mixing of old/new along the same strand; “evolutionary theory” is not a DNA replication model.


Common Pitfalls:
Confusing “semi-conservative” (one old + one new strand) with “dispersive” (mosaic within each strand).


Final Answer:
Dispersive theory

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