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- Question
Infants are most susceptible to bacterial infection due to low circulating levels of IgG
Options- A. in utero (before birth)
- B. at 0-3 months of age
- C. at 3-12 months of age
- D. at 12-24 months of age
- Correct Answer
- at 3-12 months of age
- 1. Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with
Options- A. CTL killing of viruses
- B. dendritic cell activation to become a mature APC
- C. infected cell processing of virus peptides
- D. macrophage intracellular killing of bacteria Discuss
- 2. Specific translocations are associated with
Options- A. colon cancer
- B. breast cancer
- C. pancreatic cancer
- D. some leukemias Discuss
- 3. An autoimmune disease is
Options- A. AIDS
- B. Measles
- C. Lupus
- D. Mumps Discuss
- 4. X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be
Options- A. activation of B cells by T-independent antigens
- B. failure of B cells to provide co-stimulation for Th2 activation
- C. failure of Th2 cells to provide co-stimulation for B cell isotype switching
- D. failure of Th2 cells to provide co-stimulation for B cell proliferation Discuss
- 5. Difficulties with somatic gene therapy arise from all of the following except
Options- A. GVHD caused by mature T cells in the transplanted cells
- B. inserting a gene so that it will function properly
- C. limited life span of more mature hematopoietic cells
- D. transducing genetic material into stem cells Discuss
- 6. Retinoblastoma is due to a mutation in a
Options- A. kinase
- B. tumor supressor
- C. cyclin
- D. viral gene Discuss
- 7. DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a
Options- A. knock-out mouse for RAG-1 and RAG-2
- B. knock-out mouse for a thymus
- C. nude mouse
- D. recombinant mouse for CD3 Discuss
- 8. What is the name of the protein signaling molecule that alters glucose uptake, and where would its receptors be located?
Options- A. Insulin; many different cell types that use glucose for fuel
- B. Insulin; beta cells of the pancreas
- C. PDGF; the blood
- D. NGF; the nerves involved in simple reflexes Discuss
- 9. If a disease of the blood vessels caused the endothelial cells of the vessel to die, what effect would that have on the cellular activities associated with vasodilation?
Options- A. Nitric oxide would no longer be produced
- B. Smooth muscle cells could not be made to relax
- C. It would be more difficult to increase blood flow and reduce blood pressure
- D. All of the above Discuss
- 10. Which of the following is true about a hydrophilic signaling molecule?
Options- A. Its receptor is located in the cytosol of the target cell
- B. It might trigger a signal cascade that causes some effect in a cell
- C. Since it can enter the cell, it directly affects some specific cell process
- D. It is a steroid Discuss
Disease Associated with Immune System problems
Search Results
Correct Answer: macrophage intracellular killing of bacteria
Correct Answer: some leukemias
Correct Answer: Lupus
Correct Answer: failure of Th2 cells to provide co-stimulation for B cell isotype switching
Correct Answer: GVHD caused by mature T cells in the transplanted cells
Correct Answer: tumor supressor
Correct Answer: nude mouse
Correct Answer: Insulin; many different cell types that use glucose for fuel
Correct Answer: All of the above
Correct Answer: It might trigger a signal cascade that causes some effect in a cell
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