In a family, there are six members A, B, C, D, E and F. A and B are a married couple, A being the male member. D is the only son of C, who is the brother of A. E is the sister of D. B is the daughter-in-law of F, whose husband has died. How is E related to C ?

A is a male and married to B. So, A is the husband and B is the wife. C is the brother of A. D is the son of C. E. who is the sister of D will be the daughter of C. B is the daughter-in-law of F whose husband has died means F is the mother of A. 

Clearly. E is the daughter of C.