Which of the following statements is true for enzymatically catalyzed reaction?

• The activation energy of the reaction is lowered so that a larger proportion of the substrate qualifies to overcome it
• Additional substrate molecules are energized to overcome the activation energy of the reaction
• The activation energy of the reaction is increased, thus decreasing the likelihood that any substrate molecules will overcome it
• The activation energy of the reaction is lowered so that a fewer substrate molecules can overcome it