Researchers have developed the world's smallest ___________ board game by using dynamic DNA origami tiles.

The researchers from California Institute of Technology, United States of America (USA) made world's smallest tic-tac-toe game board using dynamic DNA microscopic organic structures that can be programmed to transform into predesigned patterns. Using this technique they fashioned a microscopic game of tic-tac-toe in which players place their X's and O's by adding special DNA tiles to the board. They had chosen to make the world's smallest version of the Italian polymath Leonardo Da Vinci's iconic painting Mona Lisa. DNA consists of a backbone and four types of molecules known as bases. These bases are adenine, guanine, cytosine, and thymine.