A N N I H I L A T I O N => N I A N L A H I O N T I
After changes, A is 6th from left.
Given word is O B S E R V A N T. After making the change as given in the question, we get the following arrangement:
T N A V R E S B O.
Amicable means Friendly or in Loveable, peaceful sense.
Then Antonyms for Amicable are Opposite of Friendly => Unfriendly, Hostile, Unpeaceful, etc...
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